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发表于 2008-10-15 09:04 AM
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骨感的脆弱
瘦美人余下的可能只有骨感。
最近的发现表明,连骨感也可能是脆弱的。其中的关键是瘦素(leptin)。
人们发现了大量的瘦素功能(附录一),但同时也发现了瘦素对骨形成的抑制作用(Pogoda et al 2005)。女运动员的骨质疏松是否与其有关呢?
参考文献
Pogoda P, Priemel M, Rueger JM, Amling M. 2005. Bone remodeling: new aspects of a key process that controls skeletal maintenance and repair. Osteoporos Int. 2005 Mar;16 Suppl 2:S18-24. Bone remodeling is the concerted interplay of two cellular activities: osteoclastic bone resorption and osteoblastic bone formation. Bone remodeling is the physiologic process that maintains bone mass, skeletal integrity and skeletal function. A molecular understanding of this process is therefore of paramount importance for almost all aspects of skeletal physiology and many facets of bone diseases. Based on the morphological observation of the BMU-"bone multicellular unit" or "bone metabolic unit"-and a wide body of in vitro data, bone remodeling was thought to be controlled locally through functional coupling of resorption and formation and vice versa. However, recent genetic studies have shown that there is no obligatory tight cross-control of bone formation and bone resorption in vivo and that there is also a central axis controlling bone formation, one aspect of bone remodeling. The molecule that inhibits bone formation through a hypothalamic relay is leptin. Following binding to its receptor located on the ventromedial nuclei of the hypothalamus, leptin's action on bone formation is mediated via a neuronal signaling cascade that involves the ss-adrenergic system. The overall goal of this review is to show how the dialogue between clinical medicine and mouse genetics helped to uncover a new concept in skeletal physiology.
附录一 新发现:leptin多种新功能
http://www.ebiotrade.com/newsf/2008-9/200893165803.htm
摘要:其实,leptin不仅仅具有燃烧脂肪的功效,leptin在维持生理平衡的能量激素中扮演了一个非常重要的角色。它还影响其它一些生理功能,如新陈代谢、生殖和骨形成。
[ 本帖最后由 刘承宜 于 2008-10-15 09:06 AM 编辑 ] |
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